Thursday, September 29, 2011

Neuropathic pain hot spots on

Han Jisheng academician of as a type of chronic pain neuropathic pain, due to the high incidence, seriously affecting the patients ' quality of life, now under increasing concern and attention.  However, the complex pathogenesis of neuropathic pain, explicit treatment of wonder drug, not much, for this reason, we had an interview with academician, HAN Ji-Sheng, who is from talking about the pathogenesis and diagnosis of neuropathic pain, details the latest treatment ideas and future research priorities. Pathogenesis of complex   a high incidence of neuropathic pain, neuralgia, refers to peripheral or central nervous system injury, disease or dysfunction caused by pain, can be divided into peripheral and central neuropathic pain. Han academicians pointed out that the pathogenesis of neuropathic pain is more complex, a variety of mechanisms can cause. Specifically, peripheral mechanisms include increased cell membrane excitability, peripheral sensitization, central mechanisms include increased cell membrane excitability, Central sensitization, neural phenomenon of high-sensitivity, and so on. Changes of ion channel in peripheral mechanisms play an important role for neuropathic pain.  After peripheral nerve injury, calcium ion channel exception repeatedly to enlarge, causing large amounts of calcium ion in the flow, causing abnormal pain and hyperalgesia. Neuropathic pain in a high incidence, incidence in the general population is about 7%, in China there are about 16 million cases of neuropathic pain. Postherpetic neuralgia and painful diabetic peripheral neuropathy is the most common of the two types of neuropathic pain, others include trigeminal neuralgia, sciatica, and so on. Postherpetic neuralgia is a continued manifestation of acute Herpes Zoster pain, the incidence of 7%~27%, and as she grew older the incidence is increasing.  Diabetic peripheral neuropathy pain in diabetic patients overall incidence is approximately 15% and diabetes rise extended time. Diagnosis to be standardized types of neuropathic pain include acupuncture, electric shocks, burning like, tear-like, knife-like pain, patients often have a decline in the quality of life and various features of the damage, often accompanied by sleep disorder, accompanied by symptoms such as anxiety and depression. &Nbsp; in terms of diagnosis, Han academicians pointed out that the diagnostic criteria of considerable challenges, there is lack of standardization of diagnosis and treatment program for clinical practice applications. Past diagnosis mainly based on the causes of neuropathic pain and nerve damage parts, according to the etiological classification of neuropathic pain. In our country, to cognitive lack of neuropathic pain in most patients, resulting in lower rates of diagnosis and treatment.  Currently Chinese scholars have recognized accurate diagnostic and assessment on importance of neuropathic pain treatment, ongoing foreign assessment scales according to Chinese actual situation of patients diagnosis and treatment norm standards help clinicians make quick diagnosis, improve neuropathic pain diagnosis. New breakthroughs in treatment access Han academicians pointed out that the medications are commonly used in the treatment of neuropathic pain, however traditional analgesics such as morphine, tramadol and acetaminophen only sensitive to some patients, treatment is not ideal. Study on the pathogenesis of neuropathic pain as the deepening of international has a clearer one, two or three line treatment. 2007 International Association for the study of pain (IASP) recommended first-line drugs including calcium channel modulators such as puruibalin (Le Ruika), tricyclic antidepressants, etc.  2010 United Kingdom National Institute for health and clinical (NICE) guide the puruibalin as a central or peripheral neuropathic pain of the recommended treatments. As new drugs in the field of neuropathic pain, Puri Bahrain inhibitory neurons euphoria, has now been a number of international guidelines (IASP, NICE and the European Confederation of Neuropa

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